Bacterial protein toxins targeting Rho GTPases
نویسندگان
چکیده
منابع مشابه
Bacterial virulence factors targeting Rho GTPases: parasitism or symbiosis?
In the past few years, an important question in microbiology has arisen from reports indicating that several pathogenic bacteria have evolved virulence factors directed towards a Ras subfamily of GTPases, namely the Rho GTPases. Progress made in studying both the virulence factors and the signaling pathways involving Rho GTPases has shed light on this crosstalk. One central question is raised b...
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The ability to modify central host cellular functions is a major advantage to many bacterial pathogens that use such strategies as part of their virulence mechanisms. Small GTPases, including Rho GTPases, make particularly attractive targets for pathogens because of their central roles in modulating cellular functions such as cytoskeletal control. Such modifications of these GTPases can include...
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Cell migration is a complex, dynamic process that involves continuous remodeling of the cellular architecture, which is needed in order for the cell to move and adapt to changes in the surrounding environment. It requires rapidly activated and spatiotemporally regulated signaling networks that enable cellular responses to external cues. Rho-family GTPases are key components of these signaling n...
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The composition of the extracellular matrix (ECM) surrounding cells is key to their behavior: it modulates their ability to proliferate, differentiate, and migrate (Giancotti and Ruoslahti, 1999). ECM components can signal directly to cells through transmembrane receptors such as inte-grins, and can also present soluble cytokines and growth factors to cells. The morphology of cells varies great...
متن کاملRho GTPases
In his review of the Ras family in 1988, Pierre Chardin speculated that an obscure subfamily of the Ras superfamily, which at that time was only known in yeast, would be conserved in mammals. He was of course right, and today the number of labs and the amount of effort being expended to understand the vast network of Rho-family signaling is enormous. Given their fundamental role in normal and d...
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ژورنال
عنوان ژورنال: FEMS Microbiology Letters
سال: 2000
ISSN: 0378-1097,1574-6968
DOI: 10.1111/j.1574-6968.2000.tb09159.x